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Protein Modification & Homeostasis
Suzhou Dushu Lake Conference Center
June 16-20, 2014

Abstract Deadline extended to: April 27 , 2014

Schedule Overview

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Organized by:

Ivan Dikic, Goethe University School of Medicine, Germany
Daniel Finley, Harvard University, USA
Jianping Jin, The University of Texas Health Science Center at Houston, USA
Jun Qin, Beijing Proteome Research Center, China
Tamotsu Yoshimori, Osaka Univeristy, Japan



We are pleased to announce Cold Spring Harbor Asia conference on Protein Modification & Homeostasis which will be held at the Suzhou Dushu Lake Conference Center in Suzhou, China, located approximately 60 miles west of Shanghai. The conference will begin at 7:00pm on the evening of Monday June 16, and will conclude after lunch on June 20, 2014.

The conference will include eight oral sessions and one poster session covering the latest findings across many topics in protein biology. Many talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Protein modification by ubiquitin and ubiquitin-like proteins plays indispensable roles in protein homeostasis. The meeting is intended to provide a format for the exchange of ideas and information in related to current studies on the structure, regulation and function of the ubiquitin and ubiquitin-like protein modification systems in biology and human diseases, as well as protein degradation by autophagy and the ubiquitin-proteasome system. The meeting will cover, but not be limited to, the following main topics.

Major Topics:
1. Substrate recognition and proteolysis
2. Regulation of autophagy and the ubiquitin-proteasome system
3. DNA damage response and cancer
4. Infection, innate immunity and the inflammatory response
5. Metabolism
6. Stem cells and developmental control
7. Interplay between protein modification systems
8. Protein modifications and therapeutic innovation

Keynote Speakers:
Wolfgang Baumeister, Max Planck Institut for Biochemistry, GERMANY
Abstract title:Unveiling the Long-Held Secrets of the 26S Proteasome

Yoshinori Ohsumi, Tokyo Institute of Technology, JAPAN
Abstract title:Molecular Machinery for Autophagosome Formation in Yeast

Invited Speakers:
David Barford, Medical Research Council, UNITED KINGDOM
Abstract title:Architecture of the anaphase-promoting complex and mechanism of degron recognition and substrate ubiquitination
Ruey-Hwa Chen, Academia Sinica, TAIWAN
Abstract title:K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking
Patrice Codogno, INSERM U410, Franc
Abstract title:STK38 kinase is a new Beclin 1 partner required for the Exo84/Beclin1 interaction mediating autophagosome formation
Xin-hua Feng, Zhejiang University, China
Abstract title:PTMs in Controlling SMAD Signaling
Ronald Hay, University of Dundee, UNITED KINGDOM
Abstract title:SUMO acts to stabilize multi-protein complexes in response to proteotoxic stress.

Kazuhiro Iwai
, Graduate School of Medicine, Kyoto University, JAPAN
Abstract title:Molecular mechanism and regulation of linear chain-mediated NF-kappaB activation
Masaaki Komatsu, Tokyo Metropolitan Institute of Medical Science, JAPAN
Abstract title:Coupling of the Keap1-Nrf2 system to autophagy
Sharad Kumar, Centre for Cancer Biology, Australia
Abstract title:Ubiquitination-mediated regulation of iron homeostasis
Shigeo Murata, University of Tokyo, JAPAN
Abstract title:Thymoproteasome generates unique peptides that elicit positive selection of developing T cells
Xiaobo Qiu, Beijing Normal University, CHINA
Abstract title:Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis
Feng Shao, National Institute of Biological Sciences, CHINA
Abstract title:Disruption of host innate immunity by Pathogen-catalyzed new posttranslational modifications
Shao-Cong Sun, The Univeristy of Texas MD Anderson Cancer Center, USA
Abstract title:Ubiquitin signaling in the regulation of immunity and oncogenesis
Nicolas Thoma, Friedrich Miescher Institute for Biomedical Research, Switzerland
Abstract title:The Cop9 signalosome - structure, mechanism and activation
Wenyi Wei, Beth Israel Deaconess Medical Center, Harvard University, USA
Abstract title:APC Cdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction
Li Yu, Tsinghua University, CHINA
Abstract title:Regulation of autophagy by protein modification
Hong Zhang, Institute of Biophysics, CAS, CHINA
Abstract title:Different autophagy gene knockout mice show distinct neurodegenerative defects
Pumin Zhang, Beijing Proteome Research Center and Baylor College of Medicine, CHINA/USA
Abstract title:The Anaphase Promoting Complex Outside Mitosis
Ning Zheng, University of Washington, USA
Abstract title:Ubiquitination and regulation of a degron- and modification-free SCF substrate in circadian clock
Qing Zhong, University of Texas Southwestern Medical Center, USA
Abstract title:Autophagy Promotes Ciliogenesis by Degrading OFD1 from Centriolar
Lee Zou, MGH Cancer Center/Harvard Medical School, USA
Abstract title:SUMO and Ubiquitin Orchestrate the Distinct Functions of SLX4 Complex in DNA Damage Repair

We encourage abstracts to contain new and unpublished materials. The abstracts must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers. Status (fellow's talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. A certain number of presentations by graduate students and postdocs in this conference will be selected as fellowship (USD $100-$500) awards. For more details, please visit

We look forward to seeing you at Suzhou in June 2014.

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Early Registration

Late Registration

Payment Deadline:

May 19, 2014

Payment Deadline:

Before Arrival





















Please kindly note:

1. Registration includes food, but does NOT include Housing. Due to requests from participants to provide more housing at lower prices, we have expanded our housing options to include some lower priced nearby hotels. After completing the online registration, you will receive a link to the full list of housing options.
*Reference Room Rate:
CNY 500 per standard room per night in the Conference Hotel (Worldhotel Grand Dushulake Suzhou)
Up from CNY 200 per standard room per night in nearby budget hotels (within 5 km)
CNY 400-700 per standard room per night in nearby 4-5 star hotels

2. The early price will be available if the full payment is finished before the exact due date.
For USD participants, we will automatically change your package price to the update one if we could not successfully charge the payment from your registered credit card before the deadline.
For CNY participants, we will automatically change your package price to the update one if our bank account could not receive your full payment by wire transfer before the deadline.

3. For late registrations, your registration materials may not be guaranteed since the order is usually made in advance.

4. Please inform us your special request on food (vegetarian, kosher…etc.) or other things during the online registration or email us as early as possible so that we could make relevant arrangement accordingly.

5. Student package is exclusively designed for all the graduate, undergraduate and doctor students who have not received the doctor degree. (Student ID will be required upon arrival).

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Cold Spring Harbor Asia Conferences
Suzhou, China


Cold Spring Harbor Asia Conferences
Suzhou Dushu Lake Conference Center
No.299 Qiyue Road
SIP/ Suzhou, Jiangsu Province, China
Phone: +86 512 6272 9029
Fax: +86 512 6272 9028